Cenforce D [Sildenafil Citrate 100mg + Dapoxetine 60mg] 160mg

Description

What is Cenforce D?

Cenforce D is a duel acting ant-ed medicine contains sildenafil citrate & dapoxetine as an active constituents used in adult men to treat erectile dysfunction & premature ejaculation.

• Sildenafil citrate (C22H30N6O4S), which has pharmacological activity, is a specific phosphodiesterase type 5 (PDE5) inhibitor that treats erectile dysfunction (ED) as it promotes blood circulation to the penis, causing erection during sexual arousal.
• Dapoxetine (C19H21NO3) belongs to the group of short-acting selective serotonin reuptake inhibitors (SSRIs) and acts through its mechanism of delaying ejaculation, thereby promoting control over the timing of ejaculation for management of premature ejaculation (PE).
• This is a dual-action drug especially meant for adult males with concomitant complaints of ED and PE, thus enhancing their sexual performance.

What are The Uses of Cenforce D Tablets?

Cenforce D tablet is used in adult men with premature ejaculation & erectile dysfunction to release a long lasting firm erection during intercours. It increase penile blood flow to the corpus cavernosum by inhibiting phosphodiesterase type 5 (PDE5) enzyme during sexual intercourse. Cyclic guanosine monophosphate (cGMP) degradation does not happen if the CYP5 enzyme is inhibited and this causes vasodilation and relaxation of the smooth muscles found in the penis. Consequently, there would be increased blood pressure, which causes an erection that can last for long. During PE treatment, Dapoxetine is used; it is a short-acting selective serotonin reuptake inhibitor (SSRI) that increases levels of serotonin in the brain necessary for delaying ejaculation reflexes. Serotonin reuptake blockade contributes to coping with premature ejaculation, thus enhancing sexual satisfaction for both partners by allowing men to have more control over when they ejaculate.

Combination Therapy:

Cenforce D works effectively with men suffering from ED and PE at the same time. Cenforce D provides a dual therapeutic strategy combating these two conditions through taking Dapoxetine and Sildenafil Citrate together in one pill, thereby improving erectile function as well as treating premature ejaculation. It serves as a recommended therapy option.

What are The Dosage Guidelines for Cenforce D Tablets?

• The standard dosage of Cenforce D is one tablet a day.
• It has to be administered around 1 to 3 hours before sexual activity.
• The precise time to consume the tablet depends on the individual’s response as well as tolerance.
• It is advised against consuming Cenforce D more than once in a 24-hour period.

How to Take a Cenforce D Tablet?

• This medicine is to be taken orally with a full glass of water. It can be taken with or without food.
• This medication is more effective if it is administered on an empty stomach. 
• When engaging in sexual activity, it is best to take this tablet between 1-3 hours before. Heavy and fatty meals should be avoided around the time of the consumption of the tablet, as these may slow down its efficacy.

Missed Dosage Guidelines:

• Erectile Dysfunction

Cenforce D is consumed when needed in erectile dysfunction so it does not usually matter if a dose is missed. Just take your tablet before having sexual intercourse next time.

• Premature Ejaculation

Likewise, Cenforce D is used in an as-needed way to cure premature ejaculation and it does not come with a constant dose schedule; thus, missed doses are not relevant.

Overdosage Guidelines:

• Symptoms

Severe hypotension (low blood pressure), prolonged erection (priapism), dizziness, fainting, or severe nausea may occur as a result of overdose on Cenforce D.

• Action

In the event of an overdose, it is crucial to get immediate medical assistance. Treatment may begin by giving support to the patient and dealing with any complications as they arise. Do not take more doses unless medically recommended.

How does the Cenforce D Tablet work?

Cenforce D is a potent combination of powerful ingredients Sildenafil & Dapoxetine used to treat erectile dysfunction & premature ejaculation. It works to release a strong & long lasting erection during the intercourse.

• How does Sildenafil citrate work?

Sildenafil citrate is a phosphodiesterase type 5 (PDE5) inhibitor works to promote blood flow to the corpora cavernosa to induce an erection during the sexual intercourse. It works by inhibiting the enzyme called phosphodiesterase type 5 (PDE5) in the penile blood vessels. This inhibition can help to prevent the breakdown of cyclic guanosine monophosphate (cGMP), a molecule that relaxes the smooth muscles and dilates blood vessels, increasing blood flow to the penis.

• How does Dapoxetin work?

In this case, early ejaculation (PE) is treated with dapoxetine by making it longer while controlling its sounds. The medication elevates serotonin within the CNS. Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) works to increase the serotonin levels in the brain by inhibiting its reuptake. Higher serotonin levels can extend the ejaculation time by modulating the ejaculatory reflex.

Find how it absorbs & eliminate as below;

# Sildenafil citrate

• Absorption

After oral administration, it is quickly absorbed, reaching peak plasma concentrations in 30 to 120 minutes (Tmax = 60 minutes).

Widely dispersed throughout the body, it binds mostly albumin to plasma proteins to the tune of about 96%.

Desmethyl Sildenafil is the main metabolite of this medication, which is mostly metabolized in the liver by cytochrome P450 enzymes, notably CYP3A4 and CYP2C9.

• Elimination

Plasma half-life is around 4 hours, and the main excretion routes are urine (≈13%) and feces (≈ 80%).

# Dapoxetine

• Absorption

It takes only a short time for absorption to take place and after one or two hours’ journey in the bloodstream, the peak plasma concentration is attained.

• Distribution

Body-wide distribution, 99% protein binding mainly by albumin.

• Metabolism

The main metabolite is inactive from a pharmacological perspective and is extensively metabolized in the liver through cytochrome P450 enzymes, especially CYP2D6.

• Elimination

Mostly eliminated through urine (about 70%) and feces (20%), with an elimination half-life of 1.5 — 2 hours.

What are The Side Effects of Cenforce D Tablets?

• Cenforce D pills are composed of Sildenafil Citrate and Dapoxetine that can cause a wide range of side effects, though they are good in treating erectile dysfunction and premature ejaculation. Common minor side effects are headaches, dizziness, flushing, and nasal congestion.
• Some people may find some gastrointestinal problems such as nausea, diarrhea, or upset stomachs.
• Additionally, patients may also experience hypotension or an irregular pulse due to the mix of both medicines. However, there are rare severe side effects such as priapism, painful prolonged erections, visual disturbances and sudden hearing loss that require immediate medical attention. 
• The occurrence of these adverse effects differs from one person to another while on medication, hence the need for consultation with a healthcare provider.

Precautions and Warnings

Given below are some precautions and warnings for Cenforce D:

• Vasodilatory effect 

The vasodilatory effect of sildenafil citrate may lead to very low blood pressure, especially among people with underlying heart diseases such as severe coronary artery disease, uncontrolled hypertension, and previous history of myocardial infarction or cerebrovascular accident. Combination with nitrates or nitric oxide donors is strictly forbidden due to a possible fatal decline in blood pressure.

• Deformed penises

For individuals suffering from deformed penises (angulation, cavernosal fibrosis, or Peyronie’s disease), caution should be exercised when using Cenforce D as it may lead to priapism, whereby erection usually lasts more than four hours.

• Mental illness

Dapoxetine is a serotonin-specific reuptake inhibitor that can make you feel dizzy, sleepy, or even lose consciousness. People who have a past of suicidal thoughts or who have a psychiatric disorder like major depressive disorder or manic-depressive illness need to avoid these side effects. If you mix Dapoxetine with other drugs that affect serotonin, like SNRIs, MAO inhibitors, or selective serotonin reuptake inhibitors (SSRIs), you could get serotonin syndrome, which is very dangerous and can even kill you.

• Mental alertness effects

This could lead to decreased cognitive functioning and impairments in performing tasks such as driving or operating heavy machinery that require mental alertness.

• Liver and kidney effects

Since Sildenafil and Dapoxetine pharmacokinetics mostly happen in the liver, people whose livers don’t work well may have high plasma amounts of these drugs, which makes them more likely to have side effects. Kidney harm is another way that drugs can be eliminated differently, which means that the dose needs to be changed or the person needs to be closely watched to avoid toxicity.

• Eyes 

People who have pre-existing severe renal or hepatic disorders may experience exacerbated or prolonged side effects due to the accumulation of this drug. Thus, it is necessary to closely monitor hepatic and renal function prior to initiating therapy.

• Drugs that block or start enzymes

The cytochrome P450 system, especially CYP3A4, breaks down Cenforce D. Strong inhibitors of this enzyme (like ketoconazole and ritonavir) can raise the levels of Sildenafil and Dapoxetine when used together, which increases the chance of side effects. In contrast, enzyme inducers like rifampin and carbamazepine may make drugs less effective.

• Alcohol and drug use

If you take this drug with alcohol or other drugs that are known to lengthen the QT interval, some bad effects, like falling, low blood pressure, or feeling dizzy, may get worse. When someone goes to the doctor, they should carefully look over all of their medications. This includes over-the-counter medicines and herbal supplements.

Before beginning treatment with Cenforce D, therefore, health care practitioners must analyze patient populations and medications in detail so as to reduce chances of the occurrence of side effects and also enhance treatment results.

Interaction

• Problems with Metabolism

Dapoxetine as well as sildenafil are predominantly metabolized in the liver.

Impairments in liver functioning may lead to the accumulation of drugs in the blood and thus increase the chances of adverse effects occurrence.

If problems with the kidneys affect how medicines leave the body, dose adjustments or close tracking are needed to keep people from becoming toxic.

• Possibility of Accumulation

Patients with serious kidney or liver problems may experience worsening side effects that last longer if they take too much of this drug. A full evaluation of the liver and kidneys’ processes should be done before starting treatment.

• Inhibitors and inducers of enzymes

CYP3A4 and other parts of the cytochrome P450 system break down Cenforce D.

Strong inhibitors (like ketoconazole and ritonavir) may raise the amounts of Sildenafil and Dapoxetine when used together, which increases the risk of side effects.

Enzyme inducers, like rifampin and carbamazepine, may make drugs less effective.

• Medication at the Same Time

You need to be cautious of drugs like alcohol or medications that may have undesired effects such as fainting, dizziness or hypotension. It is therefore necessary for anyone who consumes pharmaceuticals, whether prescribed or not, to ensure that they determine any possible interactions beforehand.

• Older People

Changes in the body that come with getting older may make older people more likely to have drug effects and side effects. Doses should be changed and close tracking should be done to avoid bad effects.

• Not for women to use

Due to a lack of safety statistics and the chance of harm to the fetus or infant, Cenforce D should not be used by women, especially while they are pregnant or breastfeeding.

• Recreational Drug Use

When taken for fun, drugs that lower blood pressure or contain nitrates can interact dangerously with Cenforce D and cause serious hypotension or heart problems.

• Alcohol consumption

Too much alcohol can make the calming effects of dapoxetine stronger and make side effects like headaches, dizziness, and low blood pressure worse. People who are taking this medicine should be told to drink less alcohol.

• Taking other precautions

You should talk to a healthcare provider often to make sure the treatment is still working and to lessen any side effects.

FAQs:

1) Is it safe to take more than one Cenforce D tablet in a day? 

No, one shouldn’t take more than one Cenforce D tablet in a full 24 hours.

2) Can Cenforce D cure ED and PE permanently? 

Cenforce D doesn’t fix ED or PE, but it does help people deal with their symptoms. Discuss with your healthcare provider about how long the treatment will last and how well it works.

3) Does Cenforce D interact with herbal supplements? 

If you are taking any herbal vitamins along with Cenforce D, you must inform your doctor before doing so.

4) What should I do if Cenforce D tablets are exposed to moisture? 

Cenforce D tablets are not recommended if they have come in contact with moisture and a fresh stock must be procured.

5) How long can Cenforce D be stored? 

Cenforce D can remain in storage and stay until the date of its expiry, which is typically indicated on the packaging.