Fildena Double 200mg Tablet

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Description

What is Fildena Double 200mg?

Fildena Double 200mg is a high dose treatment option used for severe erectile dysfunction. It contains Sildenafil citrate works effectively to achieve & sustain a firm erection by increasing the penile blood flow during intercourse. The primary use of this drug is to manage erectile dysfunction (ED) in adult males.

When men are sexually aroused, sildenafil citrate helps to increase blood flow by promoting vasodilation in the corpus cavernosum through nitric oxide. This enables them to achieve and sustain erections more easily. The formulation of Fildena Double 200mg is specifically designed for people who need higher doses because they require stronger effects from their medicines. There have been numerous studies on the pharmacokinetics, efficacy, and safety profile of sildenafil citrate, especially regarding its antidiabetic properties, making it widely used in clinical practice for relieving ED.

What are The Uses of Fildena Double 200mg Tablets?

Fildena Double 200mg (Sildenafil Citrate) is a powerful phosphodiesterase type 5 (PDE5) inhibitor used to treat male erectile dysfunction). It helps to release a strong penile erection during intercourse.

  • Erectile dysfunction

The inability to obtain or sustain an erection strong enough for fulfilling sexual performance is the hallmark of ED in adult males. Fildena Double 200mg is recommended for the treatment of ED.

For those who cannot respond well to smaller dosages, the greater dosage of sildenafil citrate is advantageous.

  • Pulmonary Arterial Hypertension

Sildenafil citrate is also used to treat pulmonary arterial hypertension (PAH), even though this is not its main indication. It lowers pulmonary blood pressure, relaxes pulmonary blood vessels, and increases exercise tolerance.

  • Raynaud syndrome

Raynaud syndrome is an example of vasospasm in the terminals because of cold or stress agents leading to limited blood supply to these parts and causing them to suffer consequent discoloration and pain, has been researched for an unapproved treatment.

  • Important Information to Know

Doctors should supervise the use of Fildena Double 200mg. Individual dosages must rely on individual medical histories and health indicators to avoid any adverse reactions.

What are The Dosage Guidelines for Fildena Double 200mg Tablets?

Suggested Amount: Take one tablet of 200mg only when required 30–60 minutes prior to having sex. You must not consume more than one tablet on a daily basis.

Alteration: It might be required to make modifications in terms of effectiveness and tolerance level.

How to Take Fildena Double 200mg Tablet?

Administer this tablet orally with a glass of water. You can take it with food or without. it should be noted that taking it with a high-fat meal may slow down its response time.

Take it 30–60 minutes before the intended sexual activity so that you give enough time for the drug to start working.

Missed Dosage Guidelines:

No-Set Plan:

Because Fildena Double 200mg is only taken when it’s needed to treat erectile dysfunction, there is no set plan to follow, so you don’t miss a dose.

Do Not Double Dose:

If you forget to take it before you go sexual, do not take an extra dose to make up for it. Just take the next dose when you’re told to.

Overdosage Guidelines:

Get Help Right Away:

If someone overdoses, they should get medical help right away or call a poison control center. If you take too much, you might feel very dizzy, pass out, or have an erection that lasts for a long time.

Avoid Going Over the Suggested Dose:

To avoid serious side effects or complications, do not go over the suggested daily dose of one tablet.

How does Fildena Double 200mg Tablet Work?

Fildena Double 200mg is an effective anti-ed medicine contains sildenafil citrate used to treat male erectile dysfunction. It works by blocking the PDE5 enzyme to supply more blood flow easily to the penile area. used , which is a particular inhibitor of phosphodiesterase type 5 (PDE5) that is specific to cyclic guanosine monophosphate (cGMP). The following procedures are part of its main mode of action when treating erectile dysfunction:

  • Release of nitric oxide

In the corpus cavernosum of the penis, sexual stimulation causes the release of nitric oxide (NO). cGMP levels rise as a result of guanylate cyclase being activated by nitric oxide.

  • cGMP Build-Up

The corpus cavernosum’s smooth muscle cells relax as a result of elevated cGMP levels. Greater blood flow into the penis is made possible by the dilatation of penile blood vessels, especially the helicine arteries, which is caused by the relaxing of smooth muscle.

  • PDE5 Inhibition

PDE5, the enzyme that breaks down cGMP, is inhibited by sildenafil citrate. Sildenafil citrate maintains smooth muscle relaxation and improves erectile function by prolonging the effects of cGMP by blocking PDE5.

  • Improved Penile Erection 

An erection strong enough for sexual activity is achieved when continuous blood flow into the corpus cavernosum is facilitated by the buildup of cGMP and the following extended relaxation of penile smooth muscle cells.

The PDE5 enzyme, which is mostly found in the corpus cavernosum of the penis, is the target of sildenafil citrate’s pharmacological actions. Because of its specialization, the medication is more likely to improve erectile function while having less of an impact on other vascular tissues.

Sildenafil citrate functions similarly in the treatment of pulmonary arterial hypertension by inducing pulmonary vasodilation, which lowers pulmonary vascular resistance and pressure and increases cardiac output and exercise tolerance.

What are The Side Effects of Fildena Double 200mg Tablets?

  • Headache
  • Flushing
  • Dyspepsia
  • Nasal congestion
  • Dizziness
  • Visual disturbances
  • Hearing loss
  • Back pain
  • Muscle pain
  • Nausea
  • Rash
  • Priapism (prolonged erection)
  • Hypotension (low blood pressure)
  • Tachycardia (rapid heart rate)
  • Palpitations
  • Chest pain
  • Syncope (fainting)
  • Allergic reactions (rash, itching, swelling)
  • Insomnia
  • Anxiety
  • Dry mouth
  • Vomiting
  • Diarrhoea
  • Fatigue
  • Indigestion
  • Blurred vision
  • Increased sensitivity to light
  • Blue-tinted vision
  • Epistaxis (nosebleed)
  • Myalgia (muscle pain)

Precautions & Warnings:

Use with care in people who already have heart problems like myocardial infarction, stroke, palpitations, or coronary artery disease.

On a daily basis, check your blood pressure to see if there are any effects on your cardiovascular health.

Not recommended for people who are also taking nitrates or nitric oxide donors (like nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate) because they could experience serious hypotension.

Regularly check the blood pressure of people who are taking cholesterol-lowering drugs.

Alpha-blockers and hypertension drugs may work better when combined with sildenafil to lower blood pressure.

Be careful when giving this medicine to people who have hepatic failure.

The liver is mostly responsible for breaking down sildenafil, so dosage changes may be needed.

Patients with serious renal impairment (creatinine clearance <30 mL/min) may need to change their dose because sildenafil is cleared with less water.

Concerning priapism (an erection that lasts more than 4 hours), tell your patients about the risk of this condition.

Instruct people to see a doctor right away if they have an erection that lasts longer than 4 hours to avoid damaging the tissue permanently.

Be careful if you have a history of non-arteritic anterior ischemic optic neuropathy (NAION) or are at risk for vascular diseases.

Some people have reported losing their hearing all of a sudden.

Without delay, stop using it and see a doctor if you suddenly lose your hearing.

Patients should limit their alcohol intake because it can make side effects like headaches, dizziness, and low blood pressure worse.

This is especially important for people who are taking strong CYP3A4 inhibitors (like ketoconazole, itraconazole, and erythromycin) and inducers (like rifampin and carbamazepine).

In people who have a bleeding problem or active peptic ulcers, sildenafil may make bleeding more likely.

When Not to Take Fildena Double 200mg Tablet ?

  • Nitrate Use

If you are taking nitrates or nitric oxide sources like nitroglycerin, isosorbide dinitrate, or isosorbide mononitrate, do not take Fildena Double 200 mg. This is because the two drugs can severely lower your blood pressure.

  • Severe Cardiovascular Conditions

If you have a severe cardiovascular condition that makes it unsafe for you to be sexual, like a recent myocardial attack, stroke, or unstable angina, you should not take this medicine.

  • Asthma

If you are allergic or sensitive to sildenafil or any of the other ingredients in Fildena Double 200 mg, you should not take it.

  • Serious Liver or Kidney Problems

People who have serious liver or kidney problems should not take this medicine without medical care and dose adjustments.

If you are also taking riociguat (a guanylate cyclase stimulator), don’t take Fildena Double 200 mg at the same time. This can cause your blood pressure to drop significantly.

Interaction:

  • Nitrates and Nitric Oxide Donors

These drugs should not be taken together because they can cause serious low blood pressure. Examples of these drugs are nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate.

  • Alpha-Blockers

Giving sildenafil along with alpha-blockers (like tamsulosin or doxazosin) may cause hypotension symptoms. Make sure the patient on alpha-blocker treatment is stable before starting sildenafil, and start with the lowest dose.

  • CYP3A4 Inhibitors

Strong CYP3A4 inhibitors, such as ketoconazole, itraconazole, ritonavir, and saquinavir, may greatly raise sildenafil levels in the blood, which can make its effects stronger and increase the chance of side effects. Sildenafil dose changes may be needed.

  • CYP3A4 Inducers

Strong CYP3A4 inducers, like rifampin, carbamazepine, and phenytoin, may lower sildenafil levels in the blood, which could make it less effective. This means that the person may need to be closely watched and their amount may need to be changed.

  • Hypertension Drugs

Sildenafil can make the hypotensive effects of hypertension drugs (like beta-blockers, diuretics, and ACE inhibitors) stronger. Keep a close eye on your blood pressure and change your doses as needed.

  • Warfarin

No major interactions have been seen, but care should be taken when given together, as both can affect how blood clots.

  • Erythromycin

A moderate CYP3A4 inhibitor that can raise sildenafil levels in the blood. If sildenafil is taken with erythromycin, the dose may need to be changed.

  • HIV Protease Inhibitors

Taking sildenafil with HIV protease inhibitors (like ritonavir or indinavir) greatly raises the amount of sildenafil in the blood. Start taking sildenafil at the lowest dose and watch for any bad effects.

FAQs

1) What is the molecular formula of sildenafil citrate?

The molecular formula of sildenafil citrate is C22H30N6O4S.

2) How does Fildena Double 200mg work?

The 200 mg of Fildena Double block the enzyme PDE5, raises cGMP levels, and improve blood flow to the penis to help men get and keep an erection. 

3) Is it possible to take more than a single Fildena Double 200mg tablet each day?

You must not take more than an approved amount of one tablet in one single day.

4) What are some serious adverse reactions that come with taking Fildena Double 200mg?

Notable severe side effects include abrupt hearing loss, hypotension, myocardial infarction and stroke. It’s best to consult your physician when experiencing any of these issues.

5) Can old people use Fildena Double dosage of 200mg?

Yes, they can use them, but with great caution. Doctors usually recommend smaller beginning doses as well as tight supervision during their administration.

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