Modaheal 200mg Tablet

Description

What is Modaheal 200mg?

Modaheal 200mg is a central nervous system stimulant contains modafinil used to induce wakefulness in people with excessive daytime sleepiness caused by narcolepsy, obstructive sleep apnea & shift work sleep disorder. It works primarily on cognitive functions by exerting its effects on neurotransmitters such as dopamine and norepinephrine. Modafinil is the active component of Modaheal 200mg tablet.

Modafinil promotes wakefulness in people with excessive daytime sleepiness caused by narcolepsy, obstructive sleep apnea & shift work sleep disorder. It works by inhibiting the dopamine transporter & by inducing dopamine levels norepinephrine and histamine levels in the brain. It also enables orexin neurons. Also, modafinil elevates glutamate release, boosting excitatory signals, and reduces GABA, diminishing inhibitory signals to enhance wakefulness & alertness.

Its chemical formula is C15H15NO2S. Narcolepsy, obstructive sleep apnea, and shift work sleep disorder are the three conditions that are most commonly associated with excessive daytime sleepiness, which is the primary indication for its use.

What are The Uses of Modaheal 200mg Tablets?

Modaheal 200mg tablet is a wakefulness enhancing medicine used to treat excessive daytime sleepiness caused by narcolepsy, obstructive sleep apnea & shift work sleep disorder. It 

The medication modaheal 200mg, which contains modafinil as its active ingredient, is used to treat several illnesses that cause excessive sleepiness. 

Some of the symptoms are:

• Narcolepsy

Treats individuals with this chronic sleep condition, which is characterized by excessive daytime sleepiness and abrupt sleep attacks, by reducing their excessive daytime sleepiness.

• Obstructive Sleep Apnea (OSA)

Applied in conjunction with continuous positive airway pressure (CPAP) therapy to treat individuals with obstructive sleep apnea/hypopnea syndrome who nevertheless have significant daytime tiredness.

• Shift Work Sleep Disorder (SWSD)

Used to encourage wakefulness in people with this condition, which results in excessive sleepiness or insomnia due to a contradiction in the internal circadian rhythm and external work schedules.

Although there is research into off-label applications for neuropsychiatric and cognitive disorders, these indications have not yet received regulatory approval.

What are The Dosage Guidelines for Modaheal 200mg Tablets?

The typical adult dose is 200mg taken once daily.

• Narcolepsy

Administer 200mg once daily in the morning. Some patients may require up to 400mg daily in divided doses (morning and noon), although this higher dose may not provide additional benefit.

• Obstructive Sleep Apnea (OSA):

The recommended dose is 200mg once daily in the morning as an adjunct to continuous positive airway pressure (CPAP) therapy.

• Shift Work Sleep Disorder (SWSD):

Administer 200mg approximately 1 hour before the start of the work shift.

How to Take Modaheal 200mg Tablet?

Take Modaheal 200mg orally with or without food. Swallow the tablet whole with water.

Missed Dosage Guidelines:

If a dose is missed, skip it and take the next dose at the regular time the following day. Do not double the dose to make up for the missed one.

Overdosage Guidelines:

In case of overdose, seek immediate medical attention. Symptoms of overdose may include insomnia, restlessness, confusion, and increased heart rate.

How does The Modaheal 200mg Tablet Work?

The main way that modaheal 200mg, which contains modafinil, demonstrates its pharmacological effects is by acting as a wakefulness-promoting drug. Although the exact mode of action is unclear, it is thought to involve the following neurochemical pathways:

Dopaminergic Activity

• Modafinil increases extracellular dopamine concentrations in the brain by binding to the dopamine transporter (DAT) and blocking dopamine reuptake into presynaptic neurons. 
• It also improves dopaminergic transmission, which helps promote wakefulness.

Adrenergic Activation

• Improves norepinephrine release and modifies noradrenergic pathways, leading to its wakefulness-promoting effects. 
• Subsequently, it influences adrenergic systems, specifically the activation of α1-adrenergic receptors.

Orexinergic Modulation

• Has an impact on the orexin (hypocretin) system, which is essential for controlling alertness and arousal. 
• Modafinil is effective in treating sleep disturbances because it affects the pathways that orexinergic neurons in the hypothalamus use to project to different parts of the brain that are involved in wakefulness and alertness.

GABAergic and glutamatergic systems

• They increase wakefulness by increasing cortical activation and reducing GABAergic (gamma-aminobutyric acid) activity. 
• They improve glutamatergic transmission.

Together, these effects increase cortical arousal, alertness, and cognitive performance, which helps patients with narcolepsy, obstructive sleep apnea, and shift work sleep disorders who experience excessive daytime sleepiness.

What are The Side Effects of Modaheal 200mg Tablets?

The side effects of Modaheal 200mg tablets include:

• Headache
• Nausea
• Dizziness
• Insomnia
• Anxiety
• Nervousness
• Dry mouth
• Diarrhea
• Back pain
• Dyspepsia (indigestion)
• Palpitations
• Hypertension
• Rash
• Depression
• Euphoria
• Tremor
• Anorexia
• Confusion
• Tachycardia
• Chest pain

Precautions & Warnings

• Heart and Blood vessels:

Be careful if you have a history of heart problems like high blood pressure, cardiac infarction, or irregular heartbeats. Always keep an eye on your heart rate and blood pressure.

• Mental Conditions

Be careful with people who have had psychosis, depression, or manic episodes in the past. Keep an eye on them in case their mental symptoms start up or get worse.

• Problems with the liver

Patients with serious liver problems may need to have their doses changed because their bodies aren’t breaking down drugs as well. Think about starting treatment with a smaller dose.

• Renal Impairment

Be careful when giving this medicine to people who have renal impairment, because it may change how it works in their bodies. Check their kidney function on a regular basis.

• Possibility of Abuse

Look at the patient’s drug abuse risk factors. Keep an eye out for signs of misuse, abuse, or dependency.

• Taking More Than One Drug at the Same Time

Look over all of your present drugs to make sure they don’t interact with each other, especially CYP3A4 inhibitors or inducers. Check to see if the plasma levels of provigil change.

• Pregnancy and breastfeeding

Do not use during pregnancy unless the possible benefit outweighs the possible risk to the unborn child. Be careful when giving modafinil to women who are nursing, because it is passed out of the body in breast milk.

• Reactions to Hypersensitivity

Watch out for signs of dangerous skin reactions or hypersensitivity reactions, such as Stevens-Johnson syndrome, drug rash with eosinophilia and systemic symptoms (DRESS). Stop taking the medicine right away if these happens.

• Driving and Operating Machines

Tell patients that they might feel dizzy or have other effects on their central nervous system (CNS) that could make it harder for them to do things that require full mental alertness, like driving or operating machines.

• Past of Substance Abuse

Carefully evaluate patients who have a history of substance abuse or dependence before prescribing modafinil. Keep a close eye on them during treatment.

• Withdrawal Symptoms

Be aware of possible withdrawal symptoms if you stop taking the medicine all of a sudden, especially if you’ve been taking it for a long time. There may be a need for a gradual dose decrease.

• Contraceptive Efficacy

Tell patients that modafinil may make hormonal birth control less effective. Suggest extra or different non-hormonal birth control methods during treatment and for one month after stopping treatment.

Interaction

• CYP3A4 Inducers

Taking modafinil at the same time as CYP3A4 inducers (like rifampin, carbamazepine, or phenobarbital) may lower its levels in the blood, which could make it less effective.

• CYP3A4 Inhibitors

Giving modafinil with CYP3A4 inhibitors (like ketoconazole, itraconazole, or erythromycin) may raise the amount of modafinil in the blood, which can increase the risk of side effects.

• CYP2C19 Inhibitors

Drugs like diazepam, phenytoin, and propranolol that are CYP2C19-degradable may not break down as a result of modafinil. This can cause higher levels in the blood and could be harmful.

• Hormonal contraception

Plus, modafinil can make hormonal contraception less effective. This includes pills, shots, implants, and skin patches. Other methods of birth control that don’t involve hormones should be suggested during and for one month after treatment.

• Warfarin

Keep a close eye on the prothrombin time and INR because modafinil may combine with warfarin and change how well it stops blood from clotting.

• Antidepressants

Be careful when taking modafinil with SSRIs (like fluoxetine and sertraline) and tricyclic antidepressants (like clomipramine and desipramine). Modafinil can change the amount of these drugs in your blood.

• Antiepileptic Drugs

Keep an eye on patients who are taking antiepileptic drugs (like phenytoin, carbamazepine, or phenobarbital) to see if their seizure control changes. This is because modafinil may change the levels of these drugs in their plasma.

• Benzodiazepines

Modafinil may make benzodiazepines (like diazepam and midazolam) less effective, so the amount may need to be changed.

• CNS Stimulants

Taking modafinil with other CNS stimulants (like amphetamines or methylphenidate) may raise the chance of heart and brain problems.

• MAO Inhibitors

Be careful when taking modafinil with monoamine oxidase inhibitors (MAOIs) like phenelzine and tranylcypromine because they may combine in important ways that could change the levels of neurotransmitters.

• Alcohol

Tell your patients not to drink alcohol while they are taking provigil because it may increase the effects of the CNS depressant and change how the drug is broken down.

• Cyclosporine

Modafinil may lower the amount of cyclosporine in the blood, so the dose needs to be changed and the levels of cyclosporine need to be watched.

FAQs:

1) Can Modaheal 200mg cause gastrointestinal issues?

Yes, it can cause nausea, dry mouth, and diarrhea.

2) Can Modaheal 200mg cause headaches?

Yes, headaches are a common side effect.

3) Is Modaheal 200mg effective for all types of insomnia?

It is generally effective for excessive daytime sleepiness but may not be suitable for all types of insomnia.

4) Does Modaheal 200mg cause weight loss?

Some patients may experience weight loss as a side effect.

5) Is Modaheal 200mg a controlled substance?

Yes, it is classified as a Schedule IV controlled substance due to its potential for abuse and dependence