Avana 200mg Tablet

Description

What is Avana 200mg?

Avana 200mg tablet is used for the treatment of erectile dysfunction (impotence) in men. It works to enhance the penile blood flow by relaxing & increasing the smooth muscles & blood vessels. It contains Avanafil as an active ingredient used in the treatment of erectile dysfunction. Erectile dysfunction is a condition where a man is unable to achieve and/or maintain a penile erection adequate for sexual intercourse. It happens when there is decreased blood flow to the penis.

Avana 200mg is also very effective in treating the rare disease known as aspiratory blood vessel hypertension (PAH). It causes the blood vessel divider to relax, which reduces the weight and pneumonic blood vessel resistance. 

Avana 200mg (Avanafil) tablet is a phosphodiesterase type 5 inhibitor help men with erectile dysfunction (impotence) to achieve penile erection during intercourse.

What are The Uses of Avana 200mg Tablets?

Avana 200mg is used in men who are unable to achieve an erection during intercourse due to erectile dysfunction (impotence). It is used in the treatment of the following disorders:

• Erectile Dysfunction (ED)

This condition causes men to have trouble getting or keeping an erection long enough to have sexual intercourse. Having this problem occasionally is not a cause for concern. However, if it happens frequently, then it is best to seek medical attention. Psychological issues or underlying medical ailments may be the cause of ED. It causes stress, a lack of confidence, sexual refrainment, and relationship issues.

• Pulmonary Arterial Hypertension (PAH)

The right chambers of the heart pump blood to the lungs through the pulmonary arteries. In PAH, these arteries become constricted, which increases the blood pressure in them. This increases the burden on the heart. Some of the factors that can lead to the progression of this disease are genetics, HIV infection, congenital heart diseases, drug abuse, exposure to toxic materials, etc. However, only the avanafil suspension form is approved for the treatment of PAH, not the tablets. 

What are The Dosage Guidelines for Avana 200mg Tablets?

• Avana 200mg is taken on needed basis before sexual intercourse.
• The dosage of this tablet varies based on how well patient respond to the first dose.
• Take the medicine orally for 15 to 30 minutes before sexual activity.
• Only take the recommended dose once a day.
• The initial dose is usually 50mg, with or without food.
• The dose can be increased to 200mg if needed, based on effectiveness and tolerance.
• The lowest dose used is 50mg.

Missed Dosage Guidelines:

• It is taken as on needed basis.
• Do not take it if it is close to the time of the next dose.
• Do not, under any circumstances, take two doses to make up for the missed one.

Overdosage Guidelines:

The symptoms of Avana 200mg overdosage are given below. In such a situation, the patient is treated with supportive care. 

• Difficulty breathing
• Unconsciousness
• Seizures
• Blue green vision
• Blurred sight
• Abnormally enhanced side effects

How does The Avana 200mg Tablet Work?

Avana 200mg (Avanafil) tablet is a medication used to treat male erectile dysfunction. It works to achieve an erection during intercourse. Avanafil is classified as a phosphodiesterase type 5 (PDE5) inhibitor. Understanding its mechanism requires an examination of the physiological processes involved in achieving an erection.

Mechanism of Action

• Nitric Oxide Release

During sexual stimulation, nerve terminals and endothelial cells in the penis release nitric oxide (NO).

• Activation of Guanylate Cyclase

Nitric oxide activates the enzyme guanylate cyclase.

• Increase in cGMP Levels

These cells in the corpus cavernosum and penile arteries make more cyclic guanosine monophosphate (cGMP) when guanylate cyclase is turned on.

• Smooth Muscle Relaxation

Elevated cGMP levels cause the smooth muscle cells in the penile blood vessels to relax, resulting in vasodilation (the widening of blood vessels).

• Increased Blood Flow

Vasodilation enhances blood flow to the penis, causing the erectile tissues to become engorged and leading to an erection.

Role of PDE5 and Avanafil

• PDE5 Function

Phosphodiesterase type 5 (PDE5) is an enzyme that controls the process of getting an erection by breaking down cGMP and blocking its effects. People who have trouble getting or keeping an erection may have high PDE5 activity, which lowers cGMP levels and makes it harder to get or keep an erection.

• PDE5 inhibition

Avana 200 mg works by selectively blocking PDE5. By blocking PDE5, Avanafil stops cGMP from breaking down. This lets it build up and keep working on its vasodilatory benefits.

• Better sexual function

This inhibition makes it easier for smooth muscles to relax, brings more blood to the penis, and improves sexual function.

Clinical Implications

• Effectiveness and Sexual Stimulation

Avana 200 mg improves the natural erection response to sexual stimulation, but it doesn’t cause an erection on its own. For the drug to work, you need to be sexually aroused.

• Effectiveness

Avana 200 mg can improve sexual performance and erectile dysfunction for four to six hours after administration.

To sum up, Avana 200mg (Avanafil) improves erectile function by blocking PDE5. This raises cGMP levels, which relaxes smooth muscles and brings more blood to the penis during sexual contact. This makes it easier for men who have trouble getting or keeping an erection.

What are The Side Effects of Avana 200mg Tablets?

Mild to moderate side effects of Avana 200mg are:

• Headaches
• Nausea
• Dizziness
• Flushing and redness of face
• Stuffed nose
• Nosebleed 

Even though they are uncommon, severe side effects need prompt medical attention. If any of these responses are seen, contact the emergency services right away:

• Priapism, i.e., painful and prolonged erections lasting more than 4 hours.
• Seizures
• Chest pain during or after sex
• Allergic reactions like difficulty breathing, swollen lips, face, eyes, and throat, hives, etc.
• Blurred vision
• Reduced hearing
• Mental depression
•  Worsening of asthma 

Precautions & Warnings:

It’s essential to be aware of certain precautions and warnings to ensure safe and effective use. These precautions include:

• Consultation with a Healthcare Professional

If you are already taking other medicines or have a medical problem, you should talk to your PCP before starting Avana 200mg treatment. Healthcare personnel can use this meeting to see if you are a good candidate for the treatment and provide you with personalized advice based on your unique situation.

• Cardiovascular Health

Avana 200mg tablets may reduce blood pressure if taken with nitrates or alpha-blockers. Patients with heart disease or hypertension should use Avana 200mg cautiously and under medical supervision.

• Priapism

Avanafil can cause rare but serious priapism, a painful erection lasting more than four hours. To avoid penis injury, priapism patients should seek medical assistance immediately.

• Vision and Hearing Changes

Avanafil can cause impaired vision, light sensitivity, and, very rarely, abrupt vision loss. Avanafil and other PDE5 inhibitors might cause abrupt hearing loss or vertigo. Patients with these symptoms should stop taking Avana 200mg and visit a doctor.

• Allergic Reactions

Avoid Avana 200mg if you’re allergic to Avanafil or any of its constituents. Rashes, itching, swelling, and trouble breathing are allergic reactions that require medical attention.

• Driving and Operating Machinery

Avana 200mg pills may produce dizziness, which can impair driving or machinery operation. Before knowing how the drug affects them, people should avoid mentally demanding activities.

• Storage and Handling

These tablets should be stored at 20–25 °C, away from moisture and heat. Keep tablets away from children and pets and properly dispose of expired medication.

When Not to Take Avana 200mg Tablet ?

Avana 200mg tablets should not be taken in the following circumstances:

• Hypersensitivity

If you have a known hypersensitivity or allergy to Avanafil or any other ingredients in the tablet, avoid taking it.

• Nitrates

Do not take Avana 200mg if you are using nitrate medications for chest pain or heart problems. Combining Avanafil with nitrates can cause a sudden and severe drop in blood pressure, leading to serious health complications.

• Riociguat

Avoid taking it if you are using riociguat (Adempas), a medication used to treat pulmonary arterial hypertension. Combining Avanafil with Riociguat can also lead to dangerously low blood pressure.

• Heart Problems

Individuals with a history of heart disease, heart attack, stroke, or severe heart rhythm problems should avoid taking Avana 200mg due to the potential risk of adverse cardiovascular effects.

• Liver or Kidney Impairment

If you have severe liver or kidney impairment, consult your healthcare provider before taking Avana 200mg. Adjustments to the dosage may be necessary to avoid potential complications.

Interactions:

Before starting any medication, consult your doctor regarding potential interactions. Avoid or limit alcohol consumption while taking this medicine to prevent adverse effects like dizziness and changes in heart rate. Inform your doctor about all medications you’re taking, including nitroglycerin, ciprofloxacin, and fluconazole, to prevent interactions. Patients with cardiovascular diseases, kidney, or liver issues should use this medicine cautiously, with close monitoring. The priapism (prolonged painful erection) risk is higher in certain conditions. Grapefruit juice may interfere with the medicine’s effectiveness.

FAQs:

1) How much time does it take for this medication to start working?

Ans: The onset of action of Avana 200mg might be detected within 30 to 60 minutes after it is administered.

2) What is the duration of the effects of Avana 200mg ?

Ans: The duration of action of Avana 200mg in the body is 5 hours.

3) Is it advisable to consume alcohol while taking Avana 200mg?

Ans: Avoid or limit alcohol consumption while taking Avana 200mg to minimize the heightened risk of severe side effects such as dizziness, fainting, flushing, persistent headaches, and changes in heart rate.

4) Is Avana 200mg habit-forming?

Ans: No addictive properties were reported.

5) Is Avana 200mg safe for use during pregnancy?

Ans: Pregnant women should avoid using Avana 200mg.

6) Is it safe to consume Avana 200mg while breastfeeding?

Ans: It is advised against using Avana 200mg in women who are breastfeeding.