Sildigra 50mg Tablets

Description

What is Sildigra 50mg?

Sildigra 50mg tablet is an oral anti-ed medicine contains sildenafil citrate helps men suffering with erectile dysfunction (ED) to achieve a firm erection. It works by increasing blood flow in the genital area. Phosphodiesterase type 5 (PDE5) is an enzyme responsible for breaking down cGMP, a chemical that causes penile blood vessels to relax and fill with blood so as to produce erection.

When a man has difficulty in maintaining or attaining an erection during sexual activity, he is said to be suffering from male erectile dysfunction (ED). When PDE5 is inhibited, nitric oxide effects are increased, leading to more cGMP availability in the body and hence a larger amount of blood flow into the penis. The influx of blood into the corpus cavernosa of the penis causes its engorgement, making it stiff, which leads to improved erectile function and sexual satisfaction. Sildigra 50mg tablet is taken 30 minutes before the sexual relationship with or without food by mouth.

What are The Uses of Sildigra 50mg Tablets?

Sildigra 50mg is a Phosphodiesterase type 5 (PDE5) inhibitor used in adult men who is unable to attain an erection during intercourse due to erectile dysfunction. It works to induce a penile erection by inhibiting the type 5 phosphodiesterase enzyme.

• Management of Erectile Dysfunction (ED)

A phosphodiesterase type 5 (PDE5) inhibitor used to primarily treat male erectile dysfunction (ED) is Sildigra 50mg. Erectile dysfunction (ED) is characterized as the inability to achieve or maintain an erection during intercourse. By inhibiting PDE5, Sildigra 50mg enhances the actions of nitric oxide, thereby increasing blood supply to penile tissues, thus facilitating an erection when there is sexual arousal.

• Augmented Sexual Performance

Sildigra 50mg improves general sexual performance due to better erections both temporally and qualitatively. The result is higher levels of sexual pleasure and confidence in bed. Its efficiency as far as sexual improvement is concerned lies in its ability to make the smooth muscle of corpus cavernosum relax hence increasing blood flow for better erectile function.

• Off-Label Utilization in Pulmonary Arterial Hypertension (PAH)

Sildigra 50mg may be used off-label for the treatment of pulmonary arterial hypertension (PAH), a disorder marked by elevated blood pressure in the pulmonary arteries. Sildigra 50mg enhances exercise tolerance and alleviates symptoms such as dyspnea by dilating the pulmonary blood vessels.

• Mitigation of Anxiety Associated with Erectile Dysfunction

For males experiencing anxiety related to sexual performance owing to erectile dysfunction, Sildigra 50mg may alleviate the psychological distress associated with the disease. Enhancing erectile function may indirectly reduce performance anxiety and improve overall mental well-being.

• Crucial Information

Prior to utilizing Sildigra 50mg, patients must confer with a healthcare professional to ascertain its appropriateness for their particular medical condition and to address any potential hazards or contraindications.

What are The Dosage Guidelines for Sildigra 50mg Tablets?

Sildigra 50 mg is a prescription medication prescribed for the treatment of erectile dysfunction (ED). Find dosage guidelines as below:

• Standard Dosage: The typical dose is 50 mg taken 30-60 minutes before intercourse as needed.
• Maximum Frequency: Never take more than one dose in a 24-hour period.
• Adjusting Dosage: Based on effectiveness and tolerance, the dose may be adjusted as 25 mg to increased to 150 mg or more based on severty, but only under a doctor’s supervision.

How to Take Sildigra 50mg Tablet?

• Swallow the tablet whole with a glass of water. Avoid breaking or chewing it.
• For best results, take it 30-60 minutes before the sexual relationship.
• Sildigra 50 mg can be taken on an empty stomach or after a light meal. However, a high-fat meal might delay the onset of its effects.

Missed Dosage Guidelines:

Sildigra 50 mg is taken as needed, so there isn’t a strict dosing schedule. If you miss a dose (if suffering with ED) before planned sexual activity, you may take it when you remember, but ensure you don’t exceed one dose in 24 hours.

Overdosage Guidelines:

• Symptoms of Overdose: Overdosing on Sildigra can lead to serious side effects, including severe dizziness, nausea, prolonged and painful erection (priapism), or even vision and hearing issues.
• What to Do: In the event of an overdose, take immediate medical help. Priapism (an erection lasting more than 4 hours) requires urgent care to prevent long-term damage to the penis.

Always consult a healthcare provider for safe usage, especially if adjusting the dosage or if any unusual side effects occur.

How does Sildigra 50mg Tablet Work?

Sildigra 50 mg (Sildenafil Citrate) tablet promotes a strong erection in adult men who is unable to achieve a firm erection during intercourse due to the sexual dysfunction problem (impotence/erectile dysfunction).

• Mode of Action

Enzyme phosphodiesterase type 5 (PDE5), which breaks down cyclic guanosine monophosphate (cGMP) in the corpus cavernosum of the penis, is selectively inhibited by sildenafil citrate, which is present in Sildigra 50 mg. The mediation of smooth muscle tissue relaxation and an increase in blood flow during sexual excitement is largely dependent on this inhibition.

• The Method by Step

The corpus cavernosum’s nerve terminals and endothelial cells emit nitric oxide (NO) when sexual stimulation begins. GTP is converted to cyclic guanosine monophosphate (cGMP) by the enzyme guanylate cyclase, which is activated by nitric oxide.

• Mediated Vasodilation by CGMP

The corpus cavernosum’s smooth muscle cells relax as a result of cGMP, which functions as a secondary messenger. Cavernosal artery dilatation results from this relaxation, which raises blood flow to the penile tissues and engorgs the penis with blood to produce an erection.

• Function of PDE5

PDE5, which is mostly found in the penile tissues, quickly breaks down cGMP in a healthy state. Contraction of smooth muscles and the end of the erection are caused by the breakdown of cGMP.

• Sildenafil in Action

cGMP is not broken down by PDE5 inhibition provided by sildenafil citrate in Sildigra 50mg. The prolonged presence of cGMP in the corpus cavernosum caused by Sildenafil’s inhibition of this enzyme promotes smooth muscle relaxation and maintains elevated blood flow. This maneuver aids in the attainment and sustenance of an erection in the presence of sufficient sexual excitement.

• Action Duration

Following oral treatment, peak plasma concentrations of sildenafil are reached in 30 to 120 minutes due to its fast absorption. The efficacy remains for about 4 to 6 hours after beginning its action, which usually takes place within 30 to 60 minutes. The main metabolites of sildenafil are primarily excreted via feces and are predominantly degraded in the liver by enzymatic activities, particularly cytochrome P450 3A4 (CYP3A4).

What are The Side Effects of Sildigra 50mg Tablets?

Side Effects of Sildigra 50mg Tablets:

• Headache
• Flushing (redness of the face)
• Dizziness
• Nasal congestion
• Blurred vision
• Indigestion
• Nausea
• Muscle pain
• Back pain
• Skin rash
• Increased sensitivity to light
• Prolonged or painful erection (priapism)
• Low blood pressure (hypotension)

Patients should consult their healthcare provider if they experience any side effects, especially if they are severe or persistent.

Precautions & Warnings

• Precautions to Follow While Taking Sildigra 50mg:

Medical conditions like heart disease, high blood pressure, or problems with the liver or kidneys should be talked over with a doctor before starting Sildigra 50mg treatment.

• Contraindications

Patients should not take Sildigra 50 mg at the same time as nitrate-containing drugs or nitric oxide donors, as this could cause serious low blood pressure.

• Allergic Reactions

Symptoms of allergies such as rashes, itchy skin or swelling should be monitored closely by the patients. In case these symptoms occur, you are supposed to stop using it immediately and see a doctor.

This is because this medication may affect other medicines that you take.

For this reason, ensure that any herbal vitamins, vitamins, or over-the-counter medications you take are reported to your physician.

• Alcohol Usage

Those consuming Sildigra 50mg should limit their alcohol consumption since too much alcohol makes it hard to have an erection and increase its side effects as well.

• Related To Grapefruit Juice

A diet free from grapefruit or grapefruit juice might increase the blood levels of Sildenafil thus increasing chances of side effects.

• Limitations on Doses

Follow the dosage guidelines very carefully. Do not take more than one dose in 24 hours to lower the risk of undesirable effects.

• Existing Eye Problems

Carefully use Sildenafil if you have had eye problems like retinitis pigmentosa in the past, as it might impact your ability to see.

• Long-Lasting Erection

Getting medical help right away if you have a painful or long-lasting erection that lasts more than 4 hours (priapism) could cause damage.

• Heart attack or stroke recently

Speaking to your doctor before starting Sildigra 50mg therapy is important if you have recently had a stroke or heart attack, as these conditions may make you less suitable for treatment.

Interaction

• Nitrates and Donors of Nitric Oxide

When you take Sildigra 50 mg with nitrates (like nitroglycerin or isosorbide dinitrate) or nitric oxide donors at the same time, your blood pressure can drop significantly, which could be dangerous, because the nitrates or donors make your blood vessels wider. This mixture shouldn’t be used together.

• Blockers of alpha

If you take it with alpha-adrenergic blockers like prazosin or doxazosin, the affects on your blood pressure may get worse, leading to symptomatic hypotension. To stop bad things from happening, close tracking is necessary.

• Antihypertensive drugs

Taking Sildigra 50 mg with blood pressure medicines like beta-blockers or ACE inhibitors can make the affects of lowering blood pressure stronger, so it’s important to keep a close eye on the patient to avoid low blood pressure.

• CYP3A4 inhibitors and inducers

Drugs that inhibit CYP3A4 like ketoconazole, itraconazole or erythromycin can increase blood levels of sildenafil, making its side effects worse. On the other hand, drugs which induce CYP3A4, for instance, rifampin or carbamazepine decrease blood concentrations of sildenafil rendering it less effective.

• HIV protease inhibitors

Protease inhibitors such as ritonavir or saquinavir significantly raise sildenafil concentrations leading to high chances of side effects occurring. To avoid toxicity monitoring closely is recommended.

• Grapefruit Juice

Grapefruit juice has the ability to inhibit CYP3A4 leading to enhanced levels of Sildenafil in our body system that then increase chances for experiencing its side effects. As a result individuals using Sildigra 50mg should be warned against eating or drinking grapefruit as well as related products.

• Other ED medications

Taking this medicine along with other PDE5 inhibitors like tadalafil and vardenafil is not advisable because you might experience serious adverse effects including prolonged erection.

• Anticoagulants and agents that stop blood clots

Even though it’s not a direct interaction, taking Sildigra 50 mg with blood thinners (like warfarin) or platelet inhibitors (like aspirin) may raise the chance of bleeding.

• Ritonavir

When Ritonavir is taken with Sildigra 50mg, the levels of Sildenafil rise greatly, so the dose needs to be changed and the patient needs to be closely watched.

FAQs:

Q. What is the recommended storage temperature for Sildigra 50mg?

Store Sildigra 50mg at room temperature, between 20°C to 25°C (68°F to 77°F), away from moisture and direct sunlight.

Q. Are there any dietary restrictions while taking Sildigra 50mg?

There are no specific dietary restrictions while taking Sildigra 50mg, but it is advisable to avoid excessive alcohol and large, fatty meals that may delay absorption.

Q. Can Sildigra 50mg be used in conjunction with topical treatments?

Yes, Sildigra 50mg can be used with topical treatments, but ensure that all treatments are discussed with your healthcare provider to avoid potential interactions.

Q. Does Sildigra 50mg affect sleep patterns?

Sildigra 50mg is not known to directly affect sleep patterns. However, individual responses may vary, and any sleep disturbances should be discussed with a healthcare provider.

Q. How does Sildigra 50mg affect exercise capacity?

Sildigra 50mg is not intended to affect exercise capacity. If you experience any adverse effects related to exercise, consult your healthcare provider.